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Soloxine
Path: Home > Catalog > Hormones
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SoloxineŽ Tablets
(Levothyroxine Sodium Tablets, USP)
Levothyroxine sodium acts, as does endogenous thyroxine, to stimulate metabolism, growth, development and differentiation of tissues. Levothyroxine sodium is absorbed rapidly from the gastrointestinal tract after oral administration. Following absorption, the compound becomes bound to the serum alpha globulin fraction. For purposes of comparison, 0.1 mg of levothyroxine sodium elicits a clinical response approximately equal to that produced by one grain (65 mg) of desiccated thyroid. Soloxine is available in uniquely shaped, color coded tablets in eight different strengths to allow easy and convenient dosage adjustment.
Hypothyroidism is the generalized metabolic disease resulting from deficiency of the thyroid hormones levothyroxine (T4) and liothyronine (T3). Canine hypothyroidism is usually primary, i.e. due to atrophy of the thyroid gland. In the majority of cases the atrophy is associated with lymphocytic thyroiditis and in the remainder it is non-inflammatory and as of yet unknown etiology. Less than 10 percent of cases of hypothyroidism are secondary, i.e. due to deficiency of thyroid stimulating hormone (TSH). TSH deficiency may occur as a component of congenital hypopituitarism or as an acquired disorder in adult dogs, in which case it may be due to the growth of a pituitary tumor.
Soloxine provides thyroid replacement therapy in all conditions of inadequate production of thyroid hormones.
Soloxine (Levothyroxine Sodium Tablets, USP) will provide levothyroxine (T4) as a substrate for the physiologic deiodination to liothyronine (T3). Administration of levothyroxine sodium alone will result in complete physiologic thyroid replacement.
The initial recommended dose is 0.1 mg/10 lb. (4.5 kg) body weight twice daily. Dosage is then adjusted by monitoring the thyroid blood levels of the dog every four weeks until an adequate maintenance dose is established. The usual maintenance dose is 0.1 mg/10 lb. (4.5 kg) once daily.
Precautions: Administer with caution to animals with clinically significant heart disease, hypertension, or other complications for which sharply increased metabolic rate might prove hazardous.
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