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Dermalone Ointment
Path: Home > Catalog > Topicals
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DESCRIPTION:
Dermalone Ointment is a combination of nystatin, neomycin sulfate, thiostrepton and triamcinolone acetonide in a non-irritating vehicle, a polyethylene and mineral oil gel base.
Each mL contains:
Nystatin 100,000 Units
Neomycin Sulfate (equivalent to Neomycin base) 2.5 mg.
Thiostrepton 2,500 Units
Triamcinolone acetonide 1.0 mg.
Quadritop Ointment is supplied in tubes of 1/4 fl. oz. (7.5 mL), 1¼2 fl. oz. (15 mL) each with an elongated tip for easy application and in dispensing bottles of 8 ft. oz. (240 mL). The preparation is intended for local therapy in a variety of cutaneous disorders of cats and dogs; it is especially useful in disorders caused, complicated or threatened by bacterial and/or candidal (monilial) infections.
ACTIONS:
By virtue of its four active ingredients, the ointment provides four basic therapeutic effects: anti-inflammatory, antipruritic, antifungal and antibacterial. Triamcinolone acetonide is a potent synthetic corticosteroid providing rapid and prolonged symptomatic relief on topical administration. Inflammation, edema and pruritus promptly subside and lesions are permitted to heal. Nystatin is the first well-tolerated anti-fungal antibiotic of dependable efficacy for the treatment of cutaneous infections caused by Candida albicans (monilia). Nystatin is fungistatic in vitro against a variety of yeast and yeast-like fungi including many fungi pathogenic to animals. No appreciable activity is exhibited against bacteria. Thiostrepton has a high order of activity against gram-positive organisms, including many which are resistant to other antibiotics; neomycin exerts antimicrobial action against a wide range of gram-positive and gram-negative bacteria. Together they provide comprehensive therapy against those organisms responsible for most superficial bacterial infections.
INDICATIONS:
Dermalone Ointment is particularly useful in the treatment of acute and chronic otitis of varied etiologies, in interdigital cysts in cats and dogs, and in anal gland infections in dogs. The preparation is also indicated in the management of dermatologic disorders characterized by inflammation and dry or exudative dermatitis, particularly those caused, complicated, or threatened by bacterial or candidal (Candida albicans) infections. It is also of value in eczematous dermatitis, contact dermatitis, and seborrheic dermatitis; and as an adjunct in the treatment of dermatitis due to parasitic infection.
WARNING:
Clinical and experimental data have demonstrated that corticosteroids administered orally or by injection to animals may induce the first stage of parturition if used during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta and metritis.
Additionally, corticosteroids administered to dogs, rabbits, and rodents during pregnancy have resulted in cleft palate in the offspring. In dogs, other congenital anomalies have resulted; deformed forelegs, phocomelia, and anasarca.
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