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Tritop

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  • SKU
  • PRICE
  • QTY.
  • 10 grams
  • RX1-123-01
  • $19.04
  • Out of Stock

Indications:
TRITOP® (neomycin sulfate, isoflupredone acetate, tetracaine hydrochloride) Topical Ointment is indicated as treatment or adjunctive therapy for certain ear and skin conditions caused by or associated with neomycin-susceptible organisms and/or allergy. In addition, it is indicated as superficial dressing applied to minor cuts, wounds, lacerations, abrasions, and for post-surgical application where reduction of pain and inflammatory response is deemed desirable.

TRITOP Topical Ointment is useful in treating such conditions as acute otitis externa and, to a lesser degree, chronic otitis externa. It also is effective in treating anal gland infections and moist dermatitis and is a useful dressing for minor cuts, lacerations, abrasions, and post-surgical therapy.

TRITOP Topical Ointment may also be used after amputation of dewclaws, tails and claws, and after ear trimming and castrating operations.

Key Features:
TRITOP Topical Ointment contains the potent anti-inflammatory agent isoflupredone acetate 1 mg (0.1%); the antibiotic neomycin sulfate, 5 mg (0.5%) (equivalent to 3.5 mg neomycin); and the topical anesthetic tetracaine hydrochloride, 5 mg (0.5%). This combination is well suited for the treatment or adjunctive therapy of many ear and skin conditions, as well as a dressing for superficial wounds. Its action is specific as to anti-inflammatory, bactericidal, and anesthetic properties.

It has been reported by research workers that isoflupredone acetate is 14 times more potent than hydrocortisone as an anti-inflammatory steroid. Isoflupredone acetate markedly inhibits inflammatory reaction through its controlling influence on connective tissue and vascular components. Topically applied isoflupredone acetate is rapidly effective. In otitis externa, wounds of the concha, ulceration of the ear flaps, and irritated lesions of the skin, the inflammatory response may also be effectively inhibited by isoflupredone acetate.

Neomycin is a broad-spectrum antibiotic. Its antimicrobial range includes both gram-positive and gram-negative organisms commonly responsible for or associated with otic infections, such as staphylococci, streptococci, Escherichia coli, Aerobacter aerogenes, and many strains of Proteus and Pseudomonas organisms. Neomycin is unusually nontoxic for epithelial cells in tissue culture and is nonirritating in therapeutic concentrations.

Tetracaine hydrochloride is a topical anesthetic agent that is more potent than either procaine or cocaine in comparable concentrations and has greater ability than procaine to penetrate mucous membranes. The duration of anesthetic action of tetracaine exceeds that produced by either butacaine or phenacaine. Many investigators have demonstrated that local anesthesia plays a significant part in the promotion of healing, especially where pain is a prominent factor. It is believed that trauma stimulates local pain receptors, resulting in reflex vasodilation, edema, tenderness, and muscular spasm. If the reflex is abolished through use of a local anesthetic such as tetracaine, amelioration of tissue changes that interfere with healing is favored. The local anesthetic action of tetracaine has proved to be of great value in alleviating the pain reflex in painful skin and ear conditions.